Antibacterial activity test on ethanol extract fraction of Kirinyuh (Chromolaena odorata L.) leaves for multi-drug resistant organisms bacteria

The resistance of pathogenic bacteria to antibiotics is increasing due with incorrect doses, wrong diagnostics, and the target. Bacteria that have been resistant several are called multi-drug organisms (MDRO) bacteria. Bacterial some requires alternative herbal treatments, one which Chromolaena odorata L. Research must therefore be conducted on antibacterial activity ethanol extract fraction C. leaves for MDRO bacteria, such as Staphylococcus lugdunensis methicillin-resistant aureus (MRSA), Pseudomonas aeruginosa extended-spectrum beta-lactamase (ESBL), Klebsiella pneumoniae ESBL. This study aims determine Kirinyuh (C. L.) fractionation against Test results kirinyuh leaf S. MRSA, P. ESBL, K. ESBL each resulted in an inhibition zone average diameter 11.6 mm (strong), 11.5 11.13 respectively. Testing can show all tested namely Fraction 5. 5 MRSA formation zones formed 10.2 8.8 (moderate), 7.9 thin-layer chromatography showed secondary metabolites contained fifth were terpenoids, steroids, flavonoids.